Speeding up reaction time with invisible stimuli

Normal subjects react more quickly to a pair of visual stimuli than to a stimulus alone. This phenomenon is known as the redundant signal effect (RSE) and represents an example of divided visual attention in which signal processing is carried out in parallel to the advantage of response speed. A most interesting aspect of this phenomenon is that it can occur when one stimulus in a pair cannot be consciously detected because of hemianopia or unilateral extinction resulting from brain damage. Here, we report that a similar dissociation between visual awareness and visually guided behavior is present in normal subjects who show an RSE even when the luminance of one of a pair of stimuli is below detection threshold. The observed RSE cannot be attributed to probability summation because it violates Miller's race inequality and is likely to be related to neural summation between supra- and subthreshold stimuli. Given that a similar implicit RSE is present in hemispherectomy patients, we hypothesize that the site of this summation might be the superior colliculus (SC)

Late positivity does not meet the criteria to be considered a proper neural correlate of perceptual awareness

Contrastive analysis has been widely employed in the search for the electrophysiological neural correlates of consciousness. However, despite its clear logic, it has been argued that it may not succeed in isolating neural processes solely involved in the emergence of perceptual awareness. In fact, data from contrastive analysis would be contaminated by potential confounding factors reflecting distinct, though related, processes either preceding or following the conscious perception. At present, the ERP components representing the proper correlates of perceptual awareness still remain to be identified among those correlating with awareness (i.e., Visual Awareness Negativity, VAN and Late Positivity, LP). In order to dissociate visual awareness from post-perceptual confounds specifically related to decision making, we manipulated the response criterion, which affects how a percept is translated into a decision. In particular, while performing an orientation discrimination task, participants were asked to shift their response criterion across sessions. As a consequence, the resulting modulation should concern the ERP component(s) not exclusively reflecting mechanisms regulating the subjective conscious experience itself but rather the processes accompanying it. Electrophysiological results showed that N1 and P3 were sensitive to the response criterion adopted by participants. Additionally, the more the participants shifted their response criterion, the bigger the ERP modulation was; this was consequently indicative of the critical role of these components in the decision-making processes regardless of awareness level. When considering data independently from the response criterion, the aware vs. unaware contrast showed that both VAN and LP were significant. Crucially, the LP component was also modulated by the interaction of awareness and response criterion, while VAN results to be unaffected. In agreement with previous literature, these findings provide evidence supporting the hypothesis that VAN tracks the emergence of visual awareness by encoding the conscious percept, whereas LP reflects the contribution from post-perceptual processes related to response requirements. This excludes a direct functional role of this later component in giving rise to perceptual awareness

Markers of TMS-evoked visual conscious experience in a patient with altitudinal hemianopia

Abstract Transcranial magnetic stimulation (TMS) of the occipital and parietal cortices can induce phosphenes, i.e. visual sensations of light without light entering the eyes. In this paper, we adopted a TMS-EEG interactive co-registration approach with a patient (AM) showing altitudinal hemianopia. Occipital and parietal cortices in both hemispheres were stimulated while concurrently recording EEG signal. Results showed that, for all sites, neural activity differentially encoding for the presence vs. absence of a conscious experience could be found in a cluster of electrodes close to the stimulation site at an early (70 ms) time-period after TMS. The present data indicate that both occipital and parietal sites are independent early gatekeepers of perceptual awareness, thus, in line with evidence in favor of early correlates of perceptual awareness. Moreover, these data support the valuable contribution of the TMS-EEG approach in patients with visual field defects to investigate the neural processes responsible for perceptual awareness

Neural Correlates of Visuospatial Attention to Unseen Stimuli in Hemianopic Patients. A Steady-State Visual Evoked Potential Study

The relationship between attention and awareness is a topic of great interest in cognitive neuroscience. Some studies in healthy participants and hemianopic patients have shown dissociation between these two processes. In contrast, others confirmed the classic notion that the two processes are mutually exclusive. To try and cast further light on this fascinating dilemma, in the present study we have investigated the neural mechanisms of visual spatial attention when perceptual awareness is totally lacking. To do that, we monitored with steady-state visual evoked potentials (SSVEPs) the neurophysiological correlates of endogenous spatial attention to unseen stimuli presented to the blind field of hemianopic patients. Behaviourally, stimulus detection (a brief change in the orientation of a gabor grating) was absent in the blind hemifield while in the sighted field there was a lower, but non-significant, performance in hit rate with respect to a healthy control group. Importantly, however, in both blind and sighted hemifield of hemianopics (as well as in healthy participants) SSVEP recordings showed an attentional effect with higher frequency power in the attended than unattended condition. The scalp distribution of this effect was broadly in keeping with the location of the dorsal system of endogenous spatial attention. In conclusion, the present results provide evidence that the neural correlates of spatial attention are present regardless of visual awareness and this is in accord with the general hypothesis of a possible dissociation between attention and awareness

The glamor of old-style single-case studies in the neuroimaging era: insights from a patient with hemianopia

[no abstract available

Reliability in reporting perceptual experience: behaviour and electrophysiology in hemianopic patients

Patients with hemianopia can present with the so called blindsight phenomenon: the ability to perform above chance in the absence of acknowledged awareness. Proper awareness reports are, thus, crucial to distinguish pure forms of blindsight from forms of conscious, yet degraded, vision. It has in fact been recently shown that 1) dichotomous and graded measures to assess awareness can lead to different behavioural results in patients with hemianopia and that 2) different grades of perceptual clarity show different electrophysiological correlates in healthy participants. Here, in hemianopic patients, we assessed awareness by means of the four-point Perceptual Awareness Scale (PAS) and investigated its neural correlates with Event Related Potentials (ERPs). Results showed that patients, in most of the cases, can rate the clarity of their perceptual experience in a graded manner. Moreover, graded perceptual experiences correlated with the amplitude of deflections in ERPs. These results call for the need to assess perceptual awareness with graded measures and for the importance to use electrophysiological data to correlate behaviour with neural processing

Phosphene-guided transcranial magnetic stimulation of occipital but not parietal cortex suppresses stimulus visibility.

Transcranial magnetic stimulation (TMS) applied over the occipital lobe approximately 100 ms after the onset of a stimulus decreases its visibility if it appears in the location of the phosphene. Because phosphenes can also be elicited by stimulation of the parietal regions, we asked if the same procedure that is used to reduce visibility of stimuli with occipital TMS will lead to decreased stimulus visibility when TMS is applied to parietal regions. TMS was randomly applied at 0-130 ms after the onset of the stimulus in steps of 10 ms in occipital and parietal regions. Participants responded to the orientation of the line stimulus and rated its visibility. We replicate previous reports of phosphenes from both occipital and parietal TMS. As previously reported, we also observed visual suppression around the classical 100 ms window both in the objective line orientation and subjective visibility responses with occipital TMS. Parietal stimulation, on the other hand, did not consistently reduce stimulus visibility in any time window. http://dx.doi.org/10.1007/s00221-014-3923-z

Graph analysis of TMS–EEG connectivity reveals hemispheric differences following occipital stimulation

(1) Background: Transcranial magnetic stimulation combined with electroencephalography (TMS–EEG) provides a unique opportunity to investigate brain connectivity. However, possible hemispheric asymmetries in signal propagation dynamics following occipital TMS have not been investigated. (2) Methods: Eighteen healthy participants underwent occipital single-pulse TMS at two different EEG sites, corresponding to early visual areas. We used a state-of-the-art Bayesian estimation approach to accurately estimate TMS-evoked potentials (TEPs) from EEG data, which has not been previously used in this context. To capture the rapid dynamics of information flow patterns, we implemented a self-tuning optimized Kalman (STOK) filter in conjunction with the information partial directed coherence (iPDC) measure, enabling us to derive time-varying connectivity matrices. Subsequently, graph analysis was conducted to assess key network properties, providing insight into the overall network organization of the brain network. (3) Results: Our findings revealed distinct lateralized effects on effective brain connectivity and graph networks after TMS stimulation, with left stimulation facilitating enhanced communication between contralateral frontal regions and right stimulation promoting increased intra-hemispheric ipsilateral connectivity, as evidenced by statistical test (p < 0.001). (4) Conclusions: The identified hemispheric differences in terms of connectivity provide novel insights into brain networks involved in visual information processing, revealing the hemispheric specificity of neural responses to occipital stimulation

Olfaction and gustation in blindness: a state of the art of the literature

To date, there are quite a few studies assessing olfaction and gustation in blindness, with great variability in sample size, participants' age, blindness onset and smell and taste evaluation methods. Indeed, the evaluation of olfactory and gustatory performance can differ depending on several factors, including cultural differences. Therefore, here we analysed through a narrative review, all the works reporting a smell and taste assessment in blind individuals during the last 130 years, trying to summarize and address the knowledge in this field